New paradigms are single applied concepts that change the realities of entire systems, bodies of knowledge and areas of human endeavor. They are Helio-centrism instead of Geo-centrism and homesteading, urbanization and agriculture instead of nomadic hunting and gathering.
Current paradigms are usually unconscious due to their being long acculturated in general, and because new paradigms are always in complete conceptual opposition to the present paradigm, there is resistance to them both because of the over acculturation of logic in the modern intellectual discipline of science and because of entrenched interests empowered by the old/present paradigm.
Scientific enquiry itself is NOT the problem, its the lack of willingness to embrace the integrative thirdness greater oneness mental discipline of Wisdom.
New paradigms are classical key integrations of opposites/thirdnesses that historically bring the most problem resolution, increases in consciousness and greater survival, and hence are synonymous with Wisdom Insights.